STAT1 inhibits T cell exhaustion and myeloid derived suppressor cell accumulation to promote anti-tumor immune responses in head and neck squamous cell carcinoma

Cancers of the oral cavity remain the sixth most diagnosed cancer worldwide, with high rates of recurrence and mortality. We determined the role of STAT1 during oral carcinogenesis using two orthotopic models in mice genetically deficient for Stat1. Metastatic (LY2) and non-metastatic (B4B8) head an...

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Vydáno v:Int J Cancer
Hlavní autoři: Ryan, Nathan, Anderson, Kelvin, Volpedo, Greta, Hamza, Omar, Varikuti, Sanjay, Satoskar, Abhay R., Oghumu, Steve
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366342/
https://ncbi.nlm.nih.gov/pubmed/31709529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32781
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