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STAT1 inhibits T cell exhaustion and myeloid derived suppressor cell accumulation to promote anti-tumor immune responses in head and neck squamous cell carcinoma

Cancers of the oral cavity remain the sixth most diagnosed cancer worldwide, with high rates of recurrence and mortality. We determined the role of STAT1 during oral carcinogenesis using two orthotopic models in mice genetically deficient for Stat1. Metastatic (LY2) and non-metastatic (B4B8) head an...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Ryan, Nathan, Anderson, Kelvin, Volpedo, Greta, Hamza, Omar, Varikuti, Sanjay, Satoskar, Abhay R., Oghumu, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366342/
https://ncbi.nlm.nih.gov/pubmed/31709529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.32781
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