DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but prediction of their benefit is challenging. Neoantigens generated through impaired non-mismatch DNA repair may result in greater ICI activity. By analyzing 1,661 ICI-treated patients, we show that deletions and mutations in...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Hsiehchen, David, Hsieh, Antony, Samstein, Robert M., Lu, Tianshi, Beg, Muhammad S., Gerber, David E., Wang, Tao, Morris, Luc G.T., Zhu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365618/
https://ncbi.nlm.nih.gov/pubmed/32676589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100034
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