Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs. Attributes such as specificity, efficacy and C...

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Udgivet i:PLoS One
Main Authors: Cameron, Beatrice, Dabdoubi, Tarik, Berthou-Soulié, Laurence, Gagnaire, Marie, Arnould, Isabelle, Severac, Anne, Soubrier, Fabienne, Morales, Jacqueline, Leighton, Philip A., Harriman, William, Ching, Kathryn, Abdiche, Yasmina, Radošević, Katarina, Bouquin, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365404/
https://ncbi.nlm.nih.gov/pubmed/32673351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235815
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