Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs. Attributes such as specificity, efficacy and C...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cameron, Beatrice, Dabdoubi, Tarik, Berthou-Soulié, Laurence, Gagnaire, Marie, Arnould, Isabelle, Severac, Anne, Soubrier, Fabienne, Morales, Jacqueline, Leighton, Philip A., Harriman, William, Ching, Kathryn, Abdiche, Yasmina, Radošević, Katarina, Bouquin, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365404/
https://ncbi.nlm.nih.gov/pubmed/32673351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235815
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