Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms

Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs. Attributes such as specificity, efficacy and C...

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Vydáno v:PLoS One
Hlavní autoři: Cameron, Beatrice, Dabdoubi, Tarik, Berthou-Soulié, Laurence, Gagnaire, Marie, Arnould, Isabelle, Severac, Anne, Soubrier, Fabienne, Morales, Jacqueline, Leighton, Philip A., Harriman, William, Ching, Kathryn, Abdiche, Yasmina, Radošević, Katarina, Bouquin, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365404/
https://ncbi.nlm.nih.gov/pubmed/32673351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235815
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