Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

The voltage‐gated sodium (Nav) channel complex is comprised of pore‐forming α subunits (Nav1.1–1.9) and accessory regulatory proteins such as the intracellular fibroblast growth factor 14 (FGF14). The cytosolic Nav1.6 C‐terminal tail binds directly to FGF14 and this interaction modifies Nav1.6‐media...

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Publicat a:Physiol Rep
Autors principals: Singh, Aditya K., Wadsworth, Paul A., Tapia, Cynthia M., Aceto, Giuseppe, Ali, Syed R., Chen, Haiying, D'Ascenzo, Marcello, Zhou, Jia, Laezza, Fernanda
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363588/
https://ncbi.nlm.nih.gov/pubmed/32671946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14505
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