Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma

The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein localization protein 4 (NPL4). However, the antitumor effects of NPL4 and disulfiram in clear cell renal cell carcinoma (ccRCC) are unclear. Here, w...

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Vydáno v:PLoS One
Hlavní autoři: Yoshino, Hirofumi, Yamada, Yasutoshi, Enokida, Hideki, Osako, Yoichi, Tsuruda, Masafumi, Kuroshima, Kazuki, Sakaguchi, Takashi, Sugita, Satoshi, Tatarano, Shuichi, Nakagawa, Masayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363112/
https://ncbi.nlm.nih.gov/pubmed/32667929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236119
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