Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 ex...

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Foilsithe in:Thorax
Main Authors: Felton, Jennifer M, Dorward, David A, Cartwright, Jennifer A, Potey, Philippe MD, Robb, Calum T, Gui, Jingang, Craig, Ruth W, Schwarze, Jürgen, Haslett, Christopher, Duffin, Rodger, Dransfield, Ian, Lucas, Christopher D, Rossi, Adriano G
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Publishing Group 2020
Ábhair:
Brief Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361019/
https://ncbi.nlm.nih.gov/pubmed/32303624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213204
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