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Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation
Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 ex...
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| Pubblicato in: | Thorax |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMJ Publishing Group
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7361019/ https://ncbi.nlm.nih.gov/pubmed/32303624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213204 |
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