Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 ex...

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Dettagli Bibliografici
Pubblicato in:Thorax
Autori principali: Felton, Jennifer M, Dorward, David A, Cartwright, Jennifer A, Potey, Philippe MD, Robb, Calum T, Gui, Jingang, Craig, Ruth W, Schwarze, Jürgen, Haslett, Christopher, Duffin, Rodger, Dransfield, Ian, Lucas, Christopher D, Rossi, Adriano G
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361019/
https://ncbi.nlm.nih.gov/pubmed/32303624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213204
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