Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation

Eosinophils are key effector cells in allergic diseases. Here we investigated Mcl-1 (an anti-apoptotic protein) in experimental allergic airway inflammation using transgenic overexpressing human Mcl-1 mice (hMcl-1) and reducing Mcl-1 by a cyclin-dependent kinase inhibitor. Overexpression of Mcl-1 ex...

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Détails bibliographiques
Publié dans:Thorax
Auteurs principaux: Felton, Jennifer M, Dorward, David A, Cartwright, Jennifer A, Potey, Philippe MD, Robb, Calum T, Gui, Jingang, Craig, Ruth W, Schwarze, Jürgen, Haslett, Christopher, Duffin, Rodger, Dransfield, Ian, Lucas, Christopher D, Rossi, Adriano G
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2020
Sujets:
Brief Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361019/
https://ncbi.nlm.nih.gov/pubmed/32303624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2019-213204
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