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NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and Chronic Toxoplasma gondii Infection

NK cells regulate CD4+ and CD8+ T cells in acute viral infection, vaccination, and the tumor microenvironment. NK cells also become exhausted in chronic activation settings. The mechanisms causing these ILC responses and their impact on adaptive immunity are unclear. CD8+ T cell exhaustion develops...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Ivanova, Daria L., Krempels, Ryan, Denton, Stephen L., Fettel, Kevin D., Saltz, Giandor M., Rach, David, Fatima, Rida, Mundhenke, Tiffany, Materi, Joshua, Dunay, Ildiko R., Gigley, Jason P.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cellular and Infection Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360721/
https://ncbi.nlm.nih.gov/pubmed/32733814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00313
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