NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and Chronic Toxoplasma gondii Infection

NK cells regulate CD4+ and CD8+ T cells in acute viral infection, vaccination, and the tumor microenvironment. NK cells also become exhausted in chronic activation settings. The mechanisms causing these ILC responses and their impact on adaptive immunity are unclear. CD8+ T cell exhaustion develops...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Ivanova, Daria L., Krempels, Ryan, Denton, Stephen L., Fettel, Kevin D., Saltz, Giandor M., Rach, David, Fatima, Rida, Mundhenke, Tiffany, Materi, Joshua, Dunay, Ildiko R., Gigley, Jason P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360721/
https://ncbi.nlm.nih.gov/pubmed/32733814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00313
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