HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

The early steps of HIV-1 infection, such as uncoating, reverse transcription, nuclear import, and transport to integration sites are incompletely understood. Here, we imaged nuclear entry and transport of HIV-1 replication complexes in cell lines, primary monocyte-derived macrophages (MDMs) and CD4(...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Francis, Ashwanth C., Marin, Mariana, Singh, Parmit K., Achuthan, Vasudevan, Prellberg, Mathew J., Palermino-Rowland, Kristina, Lan, Shuiyun, Tedbury, Philip R., Sarafianos, Stefan G., Engelman, Alan N., Melikyan, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360574/
https://ncbi.nlm.nih.gov/pubmed/32665593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17256-8
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