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Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers
Affinity maturation is a complex dynamical process allowing the immune system to generate antibodies capable of recognizing antigens. We introduce a model for the evolution of the distribution of affinities across the antibody population in germinal centers. The model is amenable to detailed mathema...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7360369/ https://ncbi.nlm.nih.gov/pubmed/32538783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55678 |
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