A Phase 1, Open-Label Study in Healthy Subjects to Evaluate the Absolute Bioavailability of AG-221 by a Microtracer Approach

INTRODUCTION: The purpose of this study was to evaluate the absolute bioavailability (BA) of AG-221 following a single oral dose of 100 mg AG-221 and an intravenous (IV) dose of ~ 100 μg AG-221 containing approximately 300 nCi of [(14)C]-AG-221. METHODS: This was a phase 1, open-label study. Six sub...

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Bibliographic Details
Published in:Oncol Ther
Main Authors: Wang, Xiaomin, Chen, Jian, Reyes, Josephine, Zhou, Simon, Palmisano, Maria, Li, Yan
Format: Artigo
Language:Inglês
Published: Springer Healthcare 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360017/
https://ncbi.nlm.nih.gov/pubmed/32700065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40487-019-0097-7
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