A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone

Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses and have been playing an increasingly prominent role in structure-based vaccines. However, the development of such immunogens is often complicated by inefficiencies in their production. To alleviate this issue,...

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Détails bibliographiques
Publié dans:bioRxiv
Auteurs principaux: Zhang, Baoshan, Chao, Cara W., Tsybovsky, Yaroslav, Abiona, Olubukola M., Hutchinson, Geoffrey B., Moliva, Juan I., Olia, Adam S., Pegu, Amarendra, Phung, Emily, Stewart-Jones, Guillaume, Verardi, Raffaello, Wang, Lingshu, Wang, Shuishu, Werner, Anne, Yang, Eun Sung, Yap, Christina, Zhou, Tongqing, Mascola, John R., Sullivan, Nancy J., Graham, Barney S., Corbett, Kizzmekia S., Kwong, Peter D.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359518/
https://ncbi.nlm.nih.gov/pubmed/32676596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.06.11.147496
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