Human B cell clonal expansion and convergent antibody responses to SARS CoV-2

During virus infection B cells are critical for the production of antibodies and protective immunity. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limite...

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Publié dans:bioRxiv
Auteurs principaux: Nielsen, Sandra C. A., Yang, Fan, Jackson, Katherine J. L., Hoh, Ramona A., Röltgen, Katharina, Stevens, Bryan, Lee, Ji-Yeun, Rustagi, Arjun, Rogers, Angela J., Powell, Abigail E., Najeeb, Javaria, Otrelo-Cardoso, Ana R., Yost, Kathryn E., Daniel, Bence, Chang, Howard Y., Satpathy, Ansuman T., Jardetzky, Theodore S., Kim, Peter S., Wang, Taia T., Pinsky, Benjamin A., Blish, Catherine A., Boyd, Scott D.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359515/
https://ncbi.nlm.nih.gov/pubmed/32676593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.08.194456
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