Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors

Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized that combinatorial targeting two tumor-associated antigens would lessen this problem and enhance the antitumor activ...

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Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Yang, Meijia, Tang, Xin, Zhang, Zongliang, Gu, Lei, Wei, Heng, Zhao, Shasha, Zhong, Kunhong, Mu, Min, Huang, Cheng, Jiang, Caiying, Xu, Jianguo, Guo, Gang, Zhou, Liangxue, Tong, Aiping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359081/
https://ncbi.nlm.nih.gov/pubmed/32685008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.43991
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