Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells

Calcific aortic valve disease (CAVD) occurs via a pathophysiological process that includes inflammation-induced osteoblastic differentiation of aortic valvular interstitial cells (AVICs). Here, we investigated the role of the anti-inflammatory compound caffeic acid phenethyl ester (CAPE) in inhibiti...

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Vydáno v:Front Pharmacol
Hlavní autoři: Liu, Ming, Li, Fei, Huang, Yuming, Zhou, Tingwen, Chen, Si, Li, Geng, Shi, Jiawei, Dong, Nianguo, Xu, Kang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358518/
https://ncbi.nlm.nih.gov/pubmed/32733235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00826
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