Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches

Protein conformational switches or allosteric proteins play a key role in the regulation of many essential biological pathways. Nonetheless, the implementation of protein conformational switches in protein design applications has proven challenging, with only a few known examples that are not deriva...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Ghanbarpour, Alireza, Pinger, Cody, Salmani, Rahele Esmatpour, Assar, Zahra, Santos, Elizabeth M., Nosrati, Meisam, Pawlowski, Kathryn, Spence, Dana, Vasileiou, Chrysoula, Jin, Xiangshu, Borhan, Babak, Geiger, James. H.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358038/
https://ncbi.nlm.nih.gov/pubmed/31557439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04664
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