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Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering

The low gene manipulation efficiency of human hematopoietic stem and progenitor cells (HSPC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Given that all current and emerging gene transfer and editing technologies are bou...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Piras, Francesco, Kajaste-Rudnitski, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357672/
https://ncbi.nlm.nih.gov/pubmed/32661282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-020-0175-3
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