Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quantified changes in contractility, voltage, and/or C...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Emerging Technologies, Methods, and Models
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357169/
https://ncbi.nlm.nih.gov/pubmed/32421822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa058
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