Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes

Cohen syndrome (CS), a rare autosomal recessive disorder, has been associated with genetic mutations in the VPS13B gene, which regulates vesicle-mediated protein sorting and transport. However, the cellular mechanism underlying CS pathogenesis in patient-derived human neurons remains unknown. We ide...

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Publicado no:J Clin Med
Main Authors: Lee, You-Kyung, Hwang, Su-Kyeong, Lee, Soo-Kyung, Yang, Jung-eun, Kwak, Ji-Hye, Seo, Hyunhyo, Ahn, Hyunjun, Lee, Yong-Seok, Kim, Janghwan, Lim, Chae-Seok, Kaang, Bong-Kiun, Lee, Jae-Hyung, Lee, Jin-A, Lee, Kyungmin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356975/
https://ncbi.nlm.nih.gov/pubmed/32560273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9061886
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