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Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR)

Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for monitoring EGFR L858R/T790M mutations....

詳細記述

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書誌詳細
出版年:Molecules
主要な著者: Fawwaz, Muammar, Mishiro, Kenji, Nishii, Ryuichi, Sawazaki, Izumi, Shiba, Kazuhiro, Kinuya, Seigo, Ogawa, Kazuma
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356761/
https://ncbi.nlm.nih.gov/pubmed/32599930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25122914
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