Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion

Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability. The binding of heparin on kallistatin has been shown to block the inhibition of KLK1 by k...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Ma, Lina, Wu, Jiawei, Zheng, Ying, Shu, Zimei, Wei, Zhenquan, Sun, Yinbiao, Carrell, Robin W., Zhou, Aiwu
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356578/
https://ncbi.nlm.nih.gov/pubmed/32481593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10060828
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