Impaired Hippocampal-cortical interactions during sleep in a mouse model of Alzheimer’s disease.

Spatial learning is impaired in humans with preclinical Alzheimer’s disease (AD). We reported similar impairments in 3xTg-AD mice learning a spatial reorientation task. Memory reactivation during sleep is critical for learning related plasticity, and memory consolidation is correlated with hippocamp...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Benthem, Sarah D., Skelin, Ivan, Moseley, Shawn C., Stimmell, Alina C., Dixon, Jessica R., Melilli, Aandreza S., Molina, Leonardo, McNaughton, Bruce L., Wilber, Aaron A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356567/
https://ncbi.nlm.nih.gov/pubmed/32470367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.04.087
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