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Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according to the progression of lung cancer. In this st...

詳細記述

保存先:
書誌詳細
出版年:Molecules
主要な著者: Kim, Dae Gyu, Park, Chul Min, Huddar, Srigouri, Lim, Semi, Kim, Sunghoon, Lee, Sunkyung
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355952/
https://ncbi.nlm.nih.gov/pubmed/32549310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25122763
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