AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis

Direct targeting of oncogenic KRAS activity is a challenge. Here the authors report that a splice variant of AIMP2, AIMP2-DX2, enhances KRAS stability by blocking ubiquitin-mediated degradation of KRAS via the E3 ligase, Smurf2, and identify a chemical that can hinder AIMP2-DX2 from interacting with...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee, Sunghoon Kim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2022-05-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-022-30149-2
Tagiau: Ychwanegu Tag
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