PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection

Patients infected with influenza are at high risk of secondary bacterial infection, which is a major proximate cause of morbidity and mortality. We have shown that in mice, prior infection with influenza results in increased inflammation and mortality upon Staphylococcus aureus infection, recapitula...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tam, Vincent C., Suen, Rosa, Treuting, Piper M., Armando, Aaron, Lucarelli, Ronald, Gorrochotegui-Escalante, Norma, Diercks, Alan H., Quehenberger, Oswald, Dennis, Edward A., Aderem, Alan, Gold, Elizabeth S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355019/
https://ncbi.nlm.nih.gov/pubmed/32581129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006343117
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