Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

Food and drug products contain diverse and abundant small-molecule additives (excipients) with unclear impacts on human physiology, drug safety, and response. Here, we evaluate their potential impact on intestinal drug absorption. By screening 136 unique compounds for inhibition of the key intestina...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zou, Ling, Spanogiannopoulos, Peter, Pieper, Lindsey M., Chien, Huan-Chieh, Cai, Wenlong, Khuri, Natalia, Pottel, Joshua, Vora, Bianca, Ni, Zhanglin, Tsakalozou, Eleftheria, Zhang, Wenjun, Shoichet, Brian K., Giacomini, Kathleen M., Turnbaugh, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355017/
https://ncbi.nlm.nih.gov/pubmed/32571913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920483117
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