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A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin

The serum haptoglobin protein (Hp) scavenges toxic hemoglobin (Hb) leaked into the bloodstream from erythrocytes. In humans, there are two frequently occurring allelic forms of Hp, resulting in three genotypes: Homozygous Hp 1-1 and Hp 2-2, and heterozygous Hp 2-1. The Hp genetic polymorphism has an...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Tamara, Sem, Franc, Vojtech, Heck, Albert J. R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355005/
https://ncbi.nlm.nih.gov/pubmed/32561649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002483117
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