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The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C

KIF3AC is a mammalian neuron-specific kinesin-2 implicated in intracellular cargo transport. It is a heterodimer of KIF3A and KIF3C motor polypeptides which have distinct biochemical and motile properties as engineered homodimers. Single-molecule motility assays show that KIF3AC moves processively a...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bensel, Brandon M., Woody, Michael S., Pyrpassopoulos, Serapion, Goldman, Yale E., Gilbert, Susan P., Ostap, E. Michael
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354928/
https://ncbi.nlm.nih.gov/pubmed/32571914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916343117
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