Spatiotemporal dynamics of innate immune signaling via RIG-I–like receptors

RIG-I, MDA5, and LGP2 comprise the RIG-I–like receptors (RLRs). RIG-I and MDA5 are essential pathogen recognition receptors sensing viral infections while LGP2 has been described as both RLR cofactor and negative regulator. After sensing and binding to viral RNA, including double-stranded RNA (dsRNA...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Esser-Nobis, Katharina, Hatfield, Lauren D., Gale, Michael
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354926/
https://ncbi.nlm.nih.gov/pubmed/32571931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921861117
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