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Safety and Biocompatibility of Aflibercept-Loaded Microsphere Thermo-Responsive Hydrogel Drug Delivery System in a Nonhuman Primate Model

PURPOSE: To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model. METHODS: A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intrav...

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Vydáno v:Transl Vis Sci Technol
Hlavní autoři: Kim, Soohyun, Kang-Mieler, Jennifer J., Liu, Wenqiang, Wang, Zhe, Yiu, Glenn, Teixeira, Leandro B. C., Mieler, William F., Thomasy, Sara M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354880/
https://ncbi.nlm.nih.gov/pubmed/32742760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.9.3.30
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