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Muscle‐specific sirtuin1 gain‐of‐function ameliorates skeletal muscle atrophy in a pre‐clinical mouse model of cerebral ischemic stroke

Stroke causes severe long‐term disability in patients due to the induction of skeletal muscle atrophy and weakness, but the molecular mechanisms remain elusive. Using a preclinical mouse model of cerebral ischemic stroke, we show that stroke robustly induced atrophy and significantly decreased SirT1...

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Detalhes bibliográficos
Publicado no:FASEB Bioadv
Main Authors: Tuntevski, Kiril, Hajira, Ameena, Nichols, Austin, Alway, Stephen E., Mohamed, Junaith S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354693/
https://ncbi.nlm.nih.gov/pubmed/32676579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2020-00017
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