Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis

BACKGROUND: MET amplifications occur in human tumors, including non-small cell lung cancer (NSCLC). MET inhibitors have demonstrated some clinical activity in MET amplified NSCLC, presumably with a gene dose effect. However, the definition of MET positivity or MET amplification as a potential oncoge...

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Vydáno v:Transl Lung Cancer Res
Hlavní autoři: Overbeck, Tobias Raphael, Cron, Dana Alina, Schmitz, Katja, Rittmeyer, Achim, Körber, Wolfgang, Hugo, Sara, Schnalke, Juliane, Lukat, Laura, Hugo, Tabea, Hinterthaner, Marc, Reuter-Jessen, Kirsten, Rosenthal, Tessa, Moecks, Joachim, Bleckmann, Annalen, Schildhaus, Hans-Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: AME Publishing Company 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354108/
https://ncbi.nlm.nih.gov/pubmed/32676323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr-19-339
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