The Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Acetylation of histone lysine residues is one of the most well-studied post-translational modifications of chromatin, selectively recognized by bromodomain ‘reader’ modules. Inhibitors of the Bromodomain and Extra Terminal domain (BET) family of bromodomains have shown profound anti-cancer and anti-...

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Publicado no:J Med Chem
Main Authors: Theodoulou, Natalie H., Bamborough, Paul, Bannister, Andrew J., Becher, Isabelle, Bit, Rino A., Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H., Gordon, Laurie, Grandi, Paola, Leveridge, Melanie, Lindon, Matthew, Michon, Anne-Marie, Molnar, Judit, Robson, Samuel C., Tomkinson, Nicholas C. O., Kouzarides, Tony, Prinjha, Rab K., Humphreys, Philip G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354103/
https://ncbi.nlm.nih.gov/pubmed/25856009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00256
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