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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Ferroptosis is widely involved in degenerative diseases in various tissues including kidney, liver and brain, and is a targetable vulnerability in clear-cell carcinomas and therapy-resistant cancers. Accumulation of phospholipid hydroperoxides in cellular membranes is recognized as the hallmark and...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Principais autores: Zou, Yilong, Li, Haoxin, Graham, Emily T., Deik, Amy A., Eaton, John K., Wang, Wenyu, Sandoval-Gomez, Gerardo, Clish, Clary B., Doench, John G., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7353921/
https://ncbi.nlm.nih.gov/pubmed/32080622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0472-6
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