Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by motor neuron apoptosis and subsequent skeletal muscle atrophy caused by oxidative and nitrosative stress, mitochondrial dysfunction, and neuroinflammation. Anthocyanins are polyphenolic compounds found in berries that pos...

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Publicat a:Nutrients
Autors principals: Koza, Lilia A., Winter, Aimee N., Holsopple, Jessica, Baybayon-Grandgeorge, Angela N., Pena, Claudia, Olson, Jeffrey R., Mazzarino, Randall C., Patterson, David, Linseman, Daniel A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7353311/
https://ncbi.nlm.nih.gov/pubmed/32570926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12061824
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