Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Cancer cells activate a telomere maintenance mechanism like telomerase in order to proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase Reverse Transcriptase (TERT) promoter mutations (TPMs) that occur in several cancer subtypes with high incidence and association w...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Posch, Alexandra, Hofer-Zeni, Sarah, Klieser, Eckhard, Primavesi, Florian, Naderlinger, Elisabeth, Brandstetter, Anita, Filipits, Martin, Urbas, Romana, Swiercynski, Stefan, Jäger, Tarkan, Winkelmann, Paul, Kiesslich, Tobias, Lu, Lingeng, Neureiter, Daniel, Stättner, Stefan, Holzmann, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352723/
https://ncbi.nlm.nih.gov/pubmed/32575418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061625
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