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Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors
Genomic instability is a hallmark of cancer related to DNA damage response (DDR) deficiencies, offering vulnerabilities for targeted treatment. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) interfere with the efficient repair of DNA damage, particularly in tumors with existing defects in DN...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7352466/ https://ncbi.nlm.nih.gov/pubmed/32526888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061502 |
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