Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds

BRAF inhibitors can delay the progression of metastatic melanoma, but resistance usually emerges, leading to relapse. Drugs simultaneously targeting two or more pathways essential for cancer growth could slow or prevent the development of resistant clones. Here, we identified pyridinyl imidazole com...

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Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Palušová, Veronika, Renzová, Tereza, Verlande, Amandine, Vaclová, Tereza, Medková, Michaela, Cetlová, Linda, Sedláčková, Miroslava, Hříbková, Hana, Slaninová, Iva, Krutá, Miriama, Rotrekl, Vladimír, Uhlířová, Hana, Křížová, Aneta, Chmelík, Radim, Veselý, Pavel, Krafčíková, Michaela, Trantírek, Lukáš, Schink, Kay Oliver, Uldrijan, Stjepan
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352453/
https://ncbi.nlm.nih.gov/pubmed/32531927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061516
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