Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds

BRAF inhibitors can delay the progression of metastatic melanoma, but resistance usually emerges, leading to relapse. Drugs simultaneously targeting two or more pathways essential for cancer growth could slow or prevent the development of resistant clones. Here, we identified pyridinyl imidazole com...

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Publicat a:Cancers (Basel)
Autors principals: Palušová, Veronika, Renzová, Tereza, Verlande, Amandine, Vaclová, Tereza, Medková, Michaela, Cetlová, Linda, Sedláčková, Miroslava, Hříbková, Hana, Slaninová, Iva, Krutá, Miriama, Rotrekl, Vladimír, Uhlířová, Hana, Křížová, Aneta, Chmelík, Radim, Veselý, Pavel, Krafčíková, Michaela, Trantírek, Lukáš, Schink, Kay Oliver, Uldrijan, Stjepan
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352453/
https://ncbi.nlm.nih.gov/pubmed/32531927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061516
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