MicroRNA-199b Downregulation Confers Resistance to 5-Fluorouracil Treatment and Predicts Poor Outcome and Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

Neoadjuvant 5-fluorouracil (5-FU)-based chemoradiotherapy followed by mesorectal excision is the current standard treatment in locally advanced rectal cancer (LARC) and the lack of complete response represents a major problem that compromises long-term patient survival. However, there is a lack of r...

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Bibliographische Detailangaben
Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Cristóbal, Ion, Rubio, Jaime, Santos, Andrea, Torrejón, Blanca, Caramés, Cristina, Imedio, Laura, Mariblanca, Sofía, Luque, Melani, Sanz-Alvarez, Marta, Zazo, Sandra, Madoz-Gúrpide, Juan, Rojo, Federico, García-Foncillas, Jesús
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352382/
https://ncbi.nlm.nih.gov/pubmed/32580513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061655
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