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Drug Sequestration in Lysosomes as One of the Mechanisms of Chemoresistance of Cancer Cells and the Possibilities of Its Inhibition

Resistance to chemotherapeutics and targeted drugs is one of the main problems in successful cancer therapy. Various mechanisms have been identified to contribute to drug resistance. One of those mechanisms is lysosome-mediated drug resistance. Lysosomes have been shown to trap certain hydrophobic w...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Hraběta, Jan, Belhajová, Marie, Šubrtová, Hana, Merlos Rodrigo, Miguel Angel, Heger, Zbyněk, Eckschlager, Tomáš
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352242/
https://ncbi.nlm.nih.gov/pubmed/32575682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124392
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