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Critical anti-CRISPR locus repression by a bi-functional Cas9 inhibitor
Bacteriophages must rapidly deploy anti-CRISPR proteins (Acrs) to inactivate the RNA-guided nucleases that enforce CRISPR-Cas adaptive immunity in their bacterial hosts. Listeria monocytogenes temperate phages encode up to three anti-Cas9 proteins, with acrIIA1 always present. AcrIIA1 inhibits Cas9...
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| Publicado no: | Cell Host Microbe |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7351615/ https://ncbi.nlm.nih.gov/pubmed/32325051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.04.002 |
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