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Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia

OBJECTIVE(S): The current study aimed to investigate the relationship of genetic polymorphism and plasma methotrexate (MTX) levels, toxicity experience and event free survival (EFS) in pediatric acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: The study included 74 ALL patients. Polymerase...

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Pubblicato in:Iran J Basic Med Sci
Autori principali: Esmaili, Mohammad Ali, Kazemi, Ahmad, Faranoush, Mohammad, Mellstedt, Hakan, Zaker, Farhad, Safa, Majid, Mehrvar, Narjes, Rezvany, Mohammad Reza
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mashhad University of Medical Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351433/
https://ncbi.nlm.nih.gov/pubmed/32695297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2020.41754.9858
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