Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell Transcriptomics

BACKGROUND: DNA variants in APOL1 associate with kidney disease, but the pathophysiologic mechanisms remain incompletely understood. Model organisms lack the APOL1 gene, limiting the degree to which disease states can be recapitulated. Here we present single-cell RNA sequencing (scRNA-seq) of genome...

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Dettagli Bibliografici
Pubblicato in:Kidney360
Autori principali: Liu, Esther, Radmanesh, Behram, Chung, Byungha H., Donnan, Michael D., Yi, Dan, Dadi, Amal, Smith, Kelly D., Himmelfarb, Jonathan, Li, Mingyao, Freedman, Benjamin S., Lin, Jennie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
Soggetti:
Original Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351353/
https://ncbi.nlm.nih.gov/pubmed/32656538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34067/KID.0000422019
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