Profiling APOL1 Nephropathy Risk Variants in Genome-Edited Kidney Organoids with Single-Cell Transcriptomics

BACKGROUND: DNA variants in APOL1 associate with kidney disease, but the pathophysiologic mechanisms remain incompletely understood. Model organisms lack the APOL1 gene, limiting the degree to which disease states can be recapitulated. Here we present single-cell RNA sequencing (scRNA-seq) of genome...

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Detalhes bibliográficos
Publicado no:Kidney360
Main Authors: Liu, Esther, Radmanesh, Behram, Chung, Byungha H., Donnan, Michael D., Yi, Dan, Dadi, Amal, Smith, Kelly D., Himmelfarb, Jonathan, Li, Mingyao, Freedman, Benjamin S., Lin, Jennie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Original Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351353/
https://ncbi.nlm.nih.gov/pubmed/32656538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.34067/KID.0000422019
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