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Harnessing the biology of IL-7 for therapeutic application

Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-...

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Bibliografiske detaljer
Udgivet i:Nat Rev Immunol
Main Authors: Mackall, Crystal L., Fry, Terry J., Gress, Ronald E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351348/
https://ncbi.nlm.nih.gov/pubmed/21508983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri2970
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