Genomic Landscape of Waldenström Macroglobulinemia and Its Impact on Treatment Strategies

Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A (17%), and CD79B (8%-15%). Deletions involving chromosome 6q are common in patients with mutated MYD88 and include genes that modulate NFKB, B...

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Pubblicato in:J Clin Oncol
Autori principali: Treon, Steven P., Xu, Lian, Guerrera, Maria Luisa, Jimenez, Cristina, Hunter, Zachary R., Liu, Xia, Demos, Maria, Gustine, Joshua, Chan, Gloria, Munshi, Manit, Tsakmaklis, Nicholas, Chen, Jiaji G., Kofides, Amanda, Sklavenitis-Pistofidis, Romanos, Bustoros, Mark, Keezer, Andrew, Meid, Kirsten, Patterson, Christopher J., Sacco, Antonio, Roccaro, Aldo, Branagan, Andrew R., Yang, Guang, Ghobrial, Irene M., Castillo, Jorge J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2020
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Review Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351339/
https://ncbi.nlm.nih.gov/pubmed/32083995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.02314
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