Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Nephrotoxicity severely limits the chemotherapeutic efficacy of cisplatin (CDDP). Oxidative stress is associated with CDDP-induced acute kidney injury (AKI). Methylglyoxal (MG) forms advanced glycation end products that elevate oxidative stress. We aimed to explore the role of MG and its metabolite...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Shih-Ming, Chen, Tsung-Hui, Chang, Hui-Ting, Lin, Tzu-Yao, Lin, Chia-Yu, Tsai, Pei-Yun, Imai, Kazuhiro, Chen, Chien-Ming, Lee, Jen-Ai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351171/
https://ncbi.nlm.nih.gov/pubmed/32649695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235849
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