Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Nephrotoxicity severely limits the chemotherapeutic efficacy of cisplatin (CDDP). Oxidative stress is associated with CDDP-induced acute kidney injury (AKI). Methylglyoxal (MG) forms advanced glycation end products that elevate oxidative stress. We aimed to explore the role of MG and its metabolite...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Chen, Shih-Ming, Chen, Tsung-Hui, Chang, Hui-Ting, Lin, Tzu-Yao, Lin, Chia-Yu, Tsai, Pei-Yun, Imai, Kazuhiro, Chen, Chien-Ming, Lee, Jen-Ai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351171/
https://ncbi.nlm.nih.gov/pubmed/32649695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235849
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge