Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis

Nephrotoxicity severely limits the chemotherapeutic efficacy of cisplatin (CDDP). Oxidative stress is associated with CDDP-induced acute kidney injury (AKI). Methylglyoxal (MG) forms advanced glycation end products that elevate oxidative stress. We aimed to explore the role of MG and its metabolite...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Chen, Shih-Ming, Chen, Tsung-Hui, Chang, Hui-Ting, Lin, Tzu-Yao, Lin, Chia-Yu, Tsai, Pei-Yun, Imai, Kazuhiro, Chen, Chien-Ming, Lee, Jen-Ai
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2020
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351171/
https://ncbi.nlm.nih.gov/pubmed/32649695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235849
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