Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal Dysfunction

BACKGROUND: Uremic toxicity may play a role in the elevated risk of developing cognitive impairment found among patients with CKD. Some uremic toxins, like indoxyl sulfate, are agonists of the transcription factor aryl hydrocarbon receptor (AhR), which is widely expressed in the central nervous syst...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Bobot, Mickaël, Thomas, Laurent, Moyon, Anaïs, Fernandez, Samantha, McKay, Nathalie, Balasse, Laure, Garrigue, Philippe, Brige, Pauline, Chopinet, Sophie, Poitevin, Stéphane, Cérini, Claire, Brunet, Philippe, Dignat-George, Françoise, Burtey, Stéphane, Guillet, Benjamin, Hache, Guillaume
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350986/
https://ncbi.nlm.nih.gov/pubmed/32527975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019070728
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